Tuesday, September 01, 2009

Complications of insulin therapy


Somogyi phenomenon also known as a low - high blood glucose response is due to excessive application of insulin caused by chronic, and it is a common complication of insulin therapy. This behavior occurs when the mechanism is a chronic excess of insulin, blood sugar more children late at night during sleep when the decline, and hence lead to patient insulin antagonistic hormone (epinephrine, growth hormone, etc.) secretion increased, so that children with elevated blood sugar in the morning with high glucose.
Low - high blood sugar reaction, due to low blood sugar mostly occurs in sleep, easily missed diagnosis. Children showed hyperhidrosis, hyperactivity, anxiety, nightmares, fear, or there screaming, and sometimes also the performance of children with abnormal behavior, severe hypoglycemia with convulsions and coma may be, but children can still stay in business after getting up. Because of the low blood sugar caused by insulin antagonistic hormone to increase a few hours later (early morning) in children with high blood sugar, a large number of diabetes, and can be accompanied by one of urine, low blood sugar after the emergence of high blood sugar. Normal blood sugar indefinite periods of time, even up to several days. As the night-time hypoglycemia-like easily ignored, often find problems have emerged urine increased, and thus increase the amount of insulin, the results often lead to increased symptoms.
When the children have the following clinical manifestations, we should pay attention to whether there is a low - high blood sugar reaction:
1, children with a 24-hour urine (defined as a 24-hour total urine volume in children with the glucose contained in the amount of quantitative determination) increased, while there exists an obvious hypoglycemia-like. Due to an increase in urine sugar, increase insulin dosage, the urine can not be a steady decline, mostly in "+ + or + + +" and "-" between the more volatile.
2, children with easy to hunger, more food, weight gain, accompanied by hepatomegaly.
3, children at night, there have been nightmares, night sweats, waking headache, nausea, urine and other higher performance.
Suspected of low - high blood sugar response in children should be measured at 2-3 at night, blood glucose and urine sugar, urine sugar, or if the normal blood sugar at night can be diagnosed with the disease-negative. Approach of this phenomenon is very simple, is to reduce the dosage of insulin. Every 2-3 days to reduce insulin dosage by about 10% better, should be careful not to short period of time to prevent excessive reduction induced by acidosis.
In short, low - high blood sugar response because the symptoms are not typical, often easily missed diagnosis of children with severe physical and mental health hazards. Therefore, parents and doctors deal with this complication to be attaches great importance to timely diagnosis and treatment done to ensure the smooth progress of the treatment of children with diabetes.

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